Indian Institute of Technology Hyderabad (IITH) is a premier institute of science and technology established in 2008. IITH has been consistently ranked in the&nbsp;<a href="https://iith.ac.in/reports/" rel="noopener noreferrer">top 10 institutes</a>&nbsp;in India for Engineering&nbsp;<a href="https://www.nirfindia.org/2021/EngineeringRanking.html" rel="noopener noreferrer" target="_blank">according to NIRF</a>&nbsp;making it one of the most coveted schools for science and technology in the country.

IITH offers&nbsp;<a href="https://iith.ac.in/academics/under-graduate/">undergraduate programs</a>&nbsp;in all the classical engineering disciplines, applied sciences, design, as well as several modern interdisciplinary areas. Students are given a flexibility to explore a broad set of areas, and potentially pursue a minor or double major in a discipline that is not their own. Students who wish to seek a deeper understanding of their own discipline are strongly encouraged to get involved in cutting-edge research with the help of a faculty to mentor them, and earn an Honors in their own field.

The very foundation of IIT Hyderabad is based on&nbsp;<a href="https://iith.ac.in/research/">research and innovation</a>. The vibrant research culture is evident from the number of patents and publications that IITH produces consistently every year. IITH offers&nbsp;<a href="https://iith.ac.in/academics/programmes-offered/">graduate programs</a>&nbsp;at both a masters, and a doctoral level, in several diverse areas. There are separate programs for technology, design, science, and liberal arts. The&nbsp;<a href="https://iith.ac.in/academics/post-graduate/">MTech program</a>&nbsp;is offered in various modes and durations to cater to the ever-growing need of postgraduate level professionals in the country.

IITH encourages and supports&nbsp;<a href="https://iic-iith.netlify.app/index.html" rel="noopener noreferrer" target="_blank">innovation and entrepreneurship</a>&nbsp;at every stage. The minor program in entrepreneurship is open to all students of IITH, and many of the courses are offered by industrialists who are entrepreneurs themselves. There are various&nbsp;<a href="https://iith.ac.in/research/centres-incubators/">innovation centers and incubators</a>&nbsp;that promote entrepreneurship and help mentor young innovators. IITH has been very successful in building tie-ups with leading academic institutions around the globe.

IITH enjoys a very special relationship with Japanese universities and industries that goes beyond academic and research collaborations. In fact, some of the iconic buildings in IITH campus will carry the signature of Japanese architecture.

IITH creates a unique holistic ecosystem for education that offers interactive learning, a very flexible academic structure, cutting-edge research, strong industry collaboration, and entrepreneurship. This is an environment which enables students and faculty to translate their dreams into realities.

IIT Hyderabad

Current scaffolds for the regeneration of anterior cruciate ligament injuries are unable to capture intricate mechanical and chemical gradients present in the natural ligament-bone interface. As a result, stress concentrations can develop at the scaffold-bone interface, leading to poor osseointegration. Hence, scaffolds that possess appropriate mechano-chemical gradients would help establish normal loading properties at the interface, while promoting scaffold integration with bone. With the long-term goal of investigating regeneration of the ligament-bone interface, this feasibility study aimed to fabricate a continuously graded mesh. Specifically, graded meshes were fabricated by co-electrospinning nanohydroxyapatite/polycaprolactone (nHAP-PCL) and poly(ester urethane) urea elastomer solutions from offset spinnerets. Next, mineral crystallites were selectively deposited on the nHAP-PCL fibers by treatment with a 5× simulated body fluid (5× SBF). X-ray diffraction and energy-dispersive spectroscopy indicated calcium-deficient hydroxyapatite-like mineral crystallites with an average Ca/P ratio of 1.48. Tensile testing demonstrated the presence of a mechanical gradient, which became more pronounced upon treatment with 5× SBF. Finally, biocompatibility of the graded meshes was verified using an MC3T3-E1 osteoprogenitor cell line. The study demonstrates that graded meshes, for potential application in interfacial tissue engineering, can be fabricated by co-electrospinning. © 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Department of Chemical Engineering

World University root node

Acta Biomaterialia

Fabrication of a model continuously graded co-electrospun mesh for regeneration of the ligament-bone interface

To alleviate material limitations of the additive manufacture of tissue scaffolds, researchers have looked to indirect fabrication approaches. The feature resolution of these processes is limited however, due to the viscous ceramic slurries that are typically employed. To alleviate these limitations, the authors look to an indirect fabrication process wherein a pattern, created using Fused Deposition Modeling, is biomimetically mineralized with an aqueous simulated body fluid, which forms a bonelike hydroxyapatite throughout the scaffold pattern. Mineralized patters are then heat treated to pyrolyze the pattern and sinter the minerals. With this process, scaffolds were created with wall thicknesses as small as 150 μm and internal channel diameters of 280-340 μm, an appropriate range for bone tissue engineering.

22nd Annual International Solid Freeform Fabrication Symposium - An Additive Manufacturing Conference, SFF 2011

Indirect tissue scaffold fabrication via fused deposition modeling and biomimetic mineralization

Unlike traditional stochastic scaffold fabrication techniques, additive manufacturing (AM) can be used to create tissue-specific three-dimensional scaffolds with controlled porosity and pore geometry. Directly fabricating scaffolds through AM methods is limited because of the relatively few biocompatible materials available for processing in AM machines. To alleviate these material limitations, an indirect fabrication method is proposed. Specifically, the authors investigate the use of Fused Deposition Modeling to fabricate scaffold patterns of varied pore size and geometry. The scaffold patterns are then mineralized with a biocompatible ceramic (hydroxyapatite). A heat treatment is then used to pyrolyze the pattern and to sinter the thin ceramic coating. The result is a biocompatible ceramic scaffold composed of hollow tubes, which may promote attachment of endothelial cells and vascularization [1]. In this paper, the authors explore the scaffold pattern fabrication and mineralization processes. Two scaffold pattern materials are tested [acrylonitrile butadiene styrene (ABS) and investment cast wax (ICW)] to determine which material is the most appropriate for scaffold mineralization and sintering. While the ICW could not be thoroughly mineralized despite a sodium hydroxide surface treatment, the ABS patterns were successfully mineralized following an oxygen plasma surface treatment. A 0.004 mm mineral coating was found on the ABS patterns that featured a strut offset of 0.3 mm, which is in the range of appropriate pore size for bone tissue engineering [2].

21st Annual International Solid Freeform Fabrication Symposium - An Additive Manufacturing Conference, SFF 2010

Towards indirect tissue scaffold fabrication via additive manufacturing and hydroxyapatite mineralization

This paper gives an outlook of how microbiologically influenced corrosion (MIC) led to the corrosion of stainless steel pipelines (which are generally considered corrosion resistant) used widely in many chemical process industries and power plants. The paper highlights the causes and effects of MIC through a case study. The paper also discusses some corrective measures that can be applied.