The effect of varying wall flexibility on the deformation of an artery during steady and pulsatile flow of blood is investigated. The artery geometry is recreated from patient-derived data for a stenosed left coronary artery. Blood flow in the artery is modeled using power-law fluid. The fluid-structure interaction of blood flow on artery wall is simulated using ANSYS 16.2, and the resulting wall deformation is documented. A comparison of wall deformation using flexibility models like Rigid, Linear Elastic, Neo-hookean, Mooney-Rivlin and Holzapfel are obtained for steady flow in the artery. The maximum wall deformation in coronary flow conditions predicted by the Holzapfel model is only around 50% that predicted by the Neo-Hookean model. The flow-induced deformations reported here for patient-derived stenosed coronary artery with physiologically accurate model are the first of its kind. These results help immensely in the planning of angioplasty. © 2016 by the authors; licensee MDPI, Basel, Switzerland.