Void growth and morphology evolution are studied using a 3D representative volume element with a spherical void embedded in an FCC single crystal. The plastic flow contours are studied to determine the scenarios leading to fully plastic flow and plastic flow with elastic region. Further, the effect of anisotropy on void growth is studied through three initial crystallographic orientations (ICOs) [100], [110], & [111] with respect to loading direction. Void growth and macroscopic stress variations with applied strain are obtained from our simulations. It is observed that the peak stress corresponds to rapid void growth initiation. The peak stress is found to be dependent on void volume fraction and ICO. Furthermore, an additional geometrical parameter, diagonal distortions (Ddi) is introduced to classify the non-spheroidal void shapes observed in deformed anisotropic crystal. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.