The vacuum system of the K=130 Room Temperature Cyclotron (RTC) (operational since 1978) has been recently modernized and the same of the K bend=520 Superconducting Cyclotron (SCC), currently under commissioning, is being deployed for remote monitoring and control. The vacuum system of RTC is designed to achieve and maintain vacuum level of 2×10-6 mbar inside 23 m3 volume of Resonator tank and DEE tank. This has been upgraded by replacing several valves, Freon units, gauges and pumps. The relay based manual control system has been replaced by PLC based automated system. The SCC vacuum system also has an elaborate arrangement comprising of turbo molecular pumping modules with associated isolation valves and characteristic gauges. This paper describes essential elements, typically used to obtain high (1×10-7 mbar) vacuum using rotary pumps, diffusion pumps and cold traps/turbo-molecular pumps and other system components such as valves, gauges and baffles. The supervisory control methodology/scheme of both the vacuum systems, developed in-house using EPICS (Experimental Physics and Industrial Control System), a standard open-source software tool for designing distributed control system, is also elaborated here. © 2011 IEEE.