A simple and practical method has been developed based on intermolecular [Pd]-catalyzed C-C and an intramolecular [Cu]-catalyzed C-O bond formations for the synthesis of flavans and benzoxepines. Interestingly, the method is amenable for the synthesis of a wide variety of flavans and benzoxepines with dense functionalities on aromatic moieties. Significantly, flavans and benzoxepines are present as core/part-structures in many biologically active natural products. © 2013 Elsevier Ltd. All rights reserved.

Satyanarayana Gedu

Department of Chemistry

B.V. Ramulu

L. Mahendar

J. Krishna

A.G.K. Reddy

B. Suchand

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Tetrahedron

Transition metals catalyzed C-C and C-O bonds formation: Facile synthesis of flavans and benzoxepines

Journal	Tetrahedron
ISSN	00404020