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Transition-Metal Catalyzed Stereoselective γ-Arylation and Friedel-Crafts Alkylation: A Concise Synthesis of Indenes
Published in Wiley-VCH Verlag
2020
Volume: 2020
   
Issue: 22
Pages: 3235 - 3242
Abstract
A highly stereoselective [Pd]-catalyzed arylation of tert-alkenols, is presented and applied to the synthesis of indenes using intramolecular Friedel–Crafts alkylation sequence. The initial Heck reaction is performed by using water as the green solvent. A simple acid triggers intramolecular alkylation in short reaction times at room temperature. Notably, indenes have been accomplished using a single column chromatography technique. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
About the journal
JournalData powered by TypesetEuropean Journal of Organic Chemistry
PublisherData powered by TypesetWiley-VCH Verlag
ISSN1434193X