Contrary to the common belief that fluid friction unilaterally determines the thermal characteristics of a microfluidic device, we show here that fluid frictional characteristics of a microfluidic device may essentially be thermally tuned, delineating a non-intuitive two-way coupling. Our experiments reveal that the interfacial phenomena triggered by thermal alteration of interfaces with certain topographical and wettability characteristics may reduce the interfacial friction to a considerable extent. This has far-ranging scientific and technological consequences towards obtaining improved throughput in microfluidic devices with applications ranging from biotechnology to electronics cooling. © 2012 American Institute of Physics.