The solubility of a drug, n-(4-ethoxyphenyl)ethanamide (phenacetin), in supercritical carbon dioxide was determined by a saturation method at (308, 318, and 328) K from (9 to 19) MPa. The solubilities in mole fraction of n-(4-ethoxyphenyl)ethanamide in supercritical carbon dioxide were in the range of 1.29 · 10-5 to 2.88 · 10-5, 1.13 · 10-5 to 3.65 · 10-5, and 0.91 · 10 -5 to 4.28 · 10-5 at (308, 318, and 328) K, respectively. The solubility data were correlated with the Peng-Robinson equation of state models and the Méndez-Santiago and Teja model. © 2010 American Chemical Society.