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Sodium alginate and gelatin hydrogels: Viscosity effect on hydrophobic drug release
U. Bhutani, A. Laha, ,
Published in Elsevier
2016
Volume: 164
   
Pages: 76 - 79
Abstract
Blend of biodegradable hydrogels like sodium alginate/gelatin (SA/G) usually requires use of chemical cross-linkers to remain stable in aqueous media for drug delivery applications. This study targets the feasibility of having an entire spectrum of a model hydrophobic drug (piperine) release i.e. from burst to controlled release, by varying polymer viscosity and molecular weight of plasticizer with minimal use of cross-linkers. Swelling study, drug-polymer interactions and morphology analysis reveal the impact of viscosity variation on polymer matrix. © 2015 Elsevier B.V.
About the journal
JournalData powered by TypesetMaterials Letters
PublisherData powered by TypesetElsevier
ISSN0167577X