Here we report single walled-carbon nanotubes (SWNTs)-based chemiresistor aptasensors for highly sensitive and selective detection of weakly or uncharged molecules using the displacement format. As a proof-of-concept we demonstrate the detection of ATP, a small weakly charged molecule, by displacement of the ssDNA anti-ATP aptamer hybridized to a small capture oligonucleotide covalently attached on SWNTs, with picomolar sensitivity and selectivity over GTP. © 2011 The Royal Society of Chemistry.

Sushmee Badhulika

Department of Electrical Engineering

B.K. Das

C. Tlili

L.N. Cella

W. Chen

A. Mulchandani

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IIT Hyderabad

Chemical Communications

Single-walled carbon nanotubes chemiresistor aptasensors for small molecules: Picomolar level detection of adenosine triphosphate

Journal	Chemical Communications
Publisher	ROYAL SOC CHEMISTRY
ISSN	13597345
Open Access	No