Most of the modern industries have multivariable processes wherein interactions exist. As the process outputs and inputs are coupled, designing controller for MIMO processes is a challenging task. The effective open-loop transfer functions (EOTFs) between the paired process input-output variables have complex high order dynamics. While many of the decoupling control methods uses effective transfer function (ETF) as an FOPDT approximation for EOTF in order to tune the controllers, their suitability is limited only to certain type of processes. In this paper, wide variety of multivariable processes have been considered and possibility for applicability of methods relying on ETFs for controller design have been explored. Further, a decoupling control method has been proposed which uses simple decoupler elements. The PI/PID controllers are designed in a straightforward manner based on the EOTFs. The proposed method doesn't involve any approximations in form of model order reduction and ensures the realizability of decoupler by simply ignoring the unrealizable functions in the decoupling elements. Simulations have been carried out on various MIMO systems and various performance indices have been evaluated and compared against existing methods to validate our finding and check the robustness of the proposed method for significant plant-model mismatch. © 2017 IEEE.