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Sequential one-pot approach for the synthesis of functionalized phthalans via Heck-reduction-cyclization (HRC) reactions
J. Krishna, P. Niharika,
Published in Royal Society of Chemistry
2015
Volume: 5
   
Issue: 34
Pages: 26749 - 26761
Abstract
An efficient and practical method is described for the direct synthesis of 1,3-dihydroisobenzofurans, an important structural motif present in biologically active natural or synthetic compounds. The reaction was performed in an almost one-pot fashion via controlled [Pd]-catalyzed intermolecular Mizoroki-Heck coupling between 2-bromobenzaldehydes and allylic alcohols followed by reduction and treatment of crude diol with a Lewis acid to give 1,3-dihydroisobenzofurans. Significantly, the method enabled the synthesis of 1,3-dihydroisobenzofurans with simple to dense functionalities on the aromatic rings. © The Royal Society of Chemistry 2015.
About the journal
JournalData powered by TypesetRSC Advances
PublisherData powered by TypesetRoyal Society of Chemistry
ISSN20462069