In this work, a sensitivity analysis of linear elastic cracked structures using two-scale Generalized Finite Element Method (GFEM) is presented. The method is based on computation of material derivatives, mutual potential energies, and direct differentiation. In a computational setting, the discrete form of the mutual potential energy release rate is simple and easy to calculate, as it only requires the multiplication of the displacement vectors and stiffness sensitivity matrices. By judiciously choosing the velocity field, the method only requires displacement response in a sub-domain close to the crack tip, thus making the method computationally efficient. The method thus requires an exact computation of displacement response in a sub-domain close to the crack tip. To this end, in this study we have used a two-scale GFEM for sensitivity analysis. GFEM is based on the enrichment of the classical finite element approximation. These enrichment functions incorporate the discontinuity response in the domain. Three numerical examples which comprise mode-I and mixed mode deformations are presented to evaluate the accuracy of the fracture parameters calculated by the proposed method. © 2014 Taylor & Francis Group, LLC.