Recrystallization behavior of cold-rolled (85%) Cu-Cr-Nb-Zr alloy was studied with the aid of differential scanning calorimetry (DSC), hardness test, optical microscopy and electron backscattered diffraction (EBSD). The activation energy for recrystallization, as determined from DSC thermograms using the Kissinger, Boswell and Ozawa methods, was found to be in the range of 209-226 kJ mol−1. The DSC thermograms were analyzed to estimate the recrystallization fraction as a function of temperature, and these results were fitted to a sigmoidal curve. The recrystallization temperature was estimated from these sigmoidal curves and found to linearly increase with the heating rate (10-40 °C min−1). The recrystallized fraction obtained from DSC studies was compared to that obtained from grain orientation spread (GOS) maps and hardness tests, with good agreement found between the three methods. The results from the DSC analysis were further validated by applying recrystallization parameters to cold-rolled sheets of the Cu-Cr-Nb-Zr alloy and through microstructural examination. © 2023, ASM International.