The use of sheathing material as a structural component in the Cold-formed steel (CFS) construction holds great potential for stability of the structure and savings in the construction cost. However, there is no robust design method to account the structural contribution of sheathing boards. This paper presents the experimental results of 107 (including unsheathed and sheathed) CFS wall frame studs subjected to out-of-plane loading to study the feasibility of using gypsum board as a structural bracing sheathing material. The test parameters include various shapes and slendernesses of the CFS frame stud, thickness of the sheathing board and spacing between the sheathing bracing connections. The out-of-plane loading is applied as it causes lateral torsional buckling in the CFS structural members thereby creates pull-through failure at the sheathing bracing connections. Moreover, the suitability of the current AISI and Eurocode specification for the design of sheathing braced CFS structural member is studied. The experimental results indicate that the lateral buckling of the symmetric shaped (against the loading axis) CFS wall frame studs can be inhibited by gypsum sheathing. Whereas most of the singly symmetric and point symmetric CFS studs exhibit lateral torsional buckling and biaxial bending, respectively, due to the inadequate bracing effect of gypsum sheathing resulting in pull-through failure at the sheathing bracing connections. Therefore, a set of limitations for the use of gypsum sheathing as a structural bracing is suggested in the form of a generalized design parameter. Finally, the experimental results indicates that the design strength of the CFS wall frame stud can be increased in the range of 39% to 595% based on the shape and slenderness. © 2020 Elsevier Ltd