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Preparation and characterization of manganese ferrite-based magnetic liposomes for hyperthermia treatment of cancer
P. Pradhan, , R. Banerjee, J. Bellare, D. Bahadur
Published in Elsevier
2007
Volume: 311
   
Issue: 1 SPEC. ISS.
Pages: 208 - 215
Abstract
Comparative evaluation of two different methods of magnetic liposomes preparation, namely thin film hydration (TFH) and double emulsion (DE) with different molar ratios of egg-phosphatidyl choline (egg-PC) and cholesterol using lauric acid coated manganese ferrite-based aqueous magnetic fluid, is reported. TFH was found to be a better method of encapsulation and TFH 2:1 (egg-PC: cholesterol) magnetic liposomes showed the highest encapsulation efficiency and comparable heating ability to that of magnetic fluids. Stealth TFH 2:1 magnetic liposomes containing DSPE-PEG2000 were three-fold more cytocompatible as compared to the magnetic fluid. Stealth TFH 2:1 manganese ferrite-based magnetic liposomes might be useful for hyperthermia treatment of cancer. © 2006 Elsevier B.V. All rights reserved.
About the journal
JournalData powered by TypesetJournal of Magnetism and Magnetic Materials
PublisherData powered by TypesetElsevier
ISSN03048853