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[Pd]-Catalyzed Intermolecular Coupling and Acid Mediated Intramolecular Cyclodehydration: One-Pot Synthesis of Indenes
P. Niharika,
Published in Wiley-VCH Verlag
2018
Volume: 2018
   
Issue: 8
Pages: 971 - 979
Abstract
An efficient one-pot synthesis of indenes from simple starting materials is presented. This process involves a dual C–C bond formation through an intermolecular Heck coupling reaction followed by acid-mediated intramolecular cyclodehydration. The strategy is amenable to various substituted aromatics to give indenes. In addition, the regioselective synthesis of benzyl styrenes in a single column purification technique through in-situ reduction of Heck products (ketones) followed by acid mediated dehydration of crude reaction mixture is presented. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
About the journal
JournalData powered by TypesetEuropean Journal of Organic Chemistry
PublisherData powered by TypesetWiley-VCH Verlag
ISSN1434193X