Benzo[c]chromones are valuable tricyclic systems of natural and biological significance. Herein, we report a concise approach of 6,6-disubstituted 6H-benzo[c]chromenes in a two-step sequence starting from ortho-bromo benzylic alcohols and arylboronic acids, using intermolecular palladium-catalyzed C−C and intramolecular N-Iodosuccinimide (NIS) mediated key C−O bonds construction. Besides, the current method explored broad substrate scope under robust conditions. Notably, the practicality of the present approach is further extended for the total synthesis of Didehydroconicol. © 2022 Wiley-VCH GmbH.

Satyanarayana Gedu

Department of Chemistry

C. Shekhar

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IIT Hyderabad

European Journal of Organic Chemistry

Palladium-Catalyzed Suzuki Coupling and NIS-Mediated Dehydrogenative Cylcoetherification: A Concise Approach to 6,6-Disubstituted 6H-benzo[c]chromenes and Total Synthesis of Didehydroconicol

Journal	Data powered by TypesetEuropean Journal of Organic Chemistry
Publisher	Data powered by TypesetJohn Wiley and Sons Inc
ISSN	1434193X