Palladium-catalyzed, hydroxy group assisted regioselective mono-arylation of 2-hydroxybiphenyls to 2-hydroxy-ortho-terphenyls is presented. Current methodology was amenable on a broad range of 2-hydroxybiphenyls as well as iodoarenes, and furnished a variety of 2-hydroxy-ortho-terphenyls in good to excellent yields. © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim