A concise and highly versatile method for the synthesis of functionalized isoindolinones is reported. Various 2-bromoanilines undergo palladium-catalyzed carbonylation with 2-formylbenzoic acid under a convenient and mild procedure to give good to excellent yields of the corresponding isoindolinones. Additionally, 2-halobenzaldehydes can be applied as substrates in palladium-catalyzed double-carbonylation to provide identical compounds in moderate to good yields. © 2014 Wiley-VCH Verlag GmbH & Co. KGaA , Weinheim.

Natte Kishore

Department of Chemistry

J. Chen

H. Li

H. Neumann

M. Beller

X.-F. Wu

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Chemistry - A European Journal

Palladium-catalyzed carbonylation of 2-bromoanilines with 2-formylbenzoic acid and 2-halobenzaldehydes: Efficient synthesis of functionalized isoindolinones

Journal	Data powered by TypesetChemistry - A European Journal
Publisher	Data powered by TypesetWiley-VCH Verlag
ISSN	09476539