An efficient protocol is described for the regioselective construction of polysubstituted functionalized naphthalenes from easily accessible ortho-(alkynyl)styrenes under mild reaction conditions. The reaction proceeds via cycloaromatization and intermolecular coupling of ortho-(alkynyl)styrenes with allylic alcohols catalyzed by PdCl2. Notably, the reaction is successful under open air as the green oxidant source. A range of functional groups (F, Cl, Br, NO2, and ester) including protecting free OH groups were found to be compatible. © 2019 American Chemical Society.

Satyanarayana Gedu

Department of Chemistry

P. Ramesh

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IIT Hyderabad

Journal of Organic Chemistry

Palladium-Catalyzed Aerobic Oxidative Coupling of ortho-(Alkynyl)styrenes with Allylic Alcohols via 6- endo-dig Cyclization: Regioselective Construction of Polysubstituted Naphthalenes

Journal	Data powered by TypesetJournal of Organic Chemistry
Publisher	Data powered by TypesetAmerican Chemical Society
ISSN	00223263