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Oxidative annulations triggered by a simple Lewis acid: Facile synthesis of benzofurans
C. Sreenivasulu, A. Gopi Krishna Reddy,
Published in Royal Society of Chemistry
2017
Volume: 4
   
Issue: 6
Pages: 972 - 977
Abstract
The first example of Lewis acid promoted efficient one-pot synthesis of benzofurans is presented. Unlike previous reports on oxidative annulations between phenols and internal acetylenes, a simple and highly facile Lewis acid mediated protocol is presented. The Lewis acid (ZnCl2) played a crucial role to promote dual (C-H and O-H) bond formation, presumably via a six-membered cyclic transition state. Significantly, a variety of benzofurans were accomplished with symmetrical/unsymmetrical acetylenes. © 2017 the Partner Organisations.
About the journal
JournalData powered by TypesetOrganic Chemistry Frontiers
PublisherData powered by TypesetRoyal Society of Chemistry
ISSN20524110