Abstract: An efficient C–C bond coupling reactions (Suzuki–Miyaura and Glaser) catalyzed by PdO/GO nano-catalyst is presented. In addition, PdO/MWCNT nano-catalyst-mediated domino one-pot synthesis of 2-alkyl/2-aryl benzofurans has been accomplished from 2-iodophenols and terminal alkynes. The formation of benzofurans proceeds through intermolecular Sonogashira reaction followed by intramolecular nucleophilic addition of internal hydroxyl group onto the acetylenic bond. The catalyst PdO/GO has been reused successfully, with nearly no loss of activity up to 5 cycles. Graphical Abstract: : Synopsis: An efficient PdO/GO and PdO/MWCNT nanocatalysts have been developed for C–C coupling reactions like Suzuki and Glaser coupling reactions, multi-catalytic one-pot synthesis of 2-aryl, 2-alkyl benzofurans staring from 2-iodophenols and terminal alkynes. The protocol involves formation of benzofuran derivatives, i.e., Sonogashira reaction followed by 2-ethynyl phenol cyclization. [Figure not available: see fulltext.] © 2018, Indian Academy of Sciences.