Everyone agrees that scientific communication should be free for all. Unfortunately, accessing publications from many reputed journals comes at a high cost—a cost that many researchers and institutions cannot afford. Although, open-access publication model is considered by many as a possible route to ensure that science is free for all; however, it is fraught with its own challenges. This review attempts at exploring the possibilities of keeping science accessible. Firstly, we re-visit the meaning of “open science” as a comprehensive concept which includes open source, data, access, resources, peer review etc. and not merely open access publication model. Next, we have discussed the global initiatives towards open access—the Budapest Open Access Initiative, Bethesda Statement on Open Access Publishing, Berlin Declaration on Open Access to Knowledge in the Sciences and Humanities, cOAlition S and its Plan S initiative, UNESCO Recommendation on Open Science and the San Francisco Declaration on Research Assessment (DORA). Following this we have included the various open access initiatives from India. In the next part, we have focused on problems with dissemination of scientific outcomes and the challenges associated with existing publication models. Finally, we explore the possible solutions to the existing challenges, which include promotion of pre-print servers and other ideas that we have detailed in the manuscript. © 2022, Indian National Science Academy.