We report ultra-selective zinc stannate nano cubes (ZnSnO3) modified glassy carbon electrode (GCE) for simultaneous detection of Uric Acid (UA) and Dopamine (DA) using differential pulse voltammetry (DPV) technique. The ZnSnO3 nano cubes were synthesized via one-pot hydrothermal technique. The orthorhombic phase formation of nano cubes structured ZnSnO3 was confirmed through X-ray diffraction (XRD) and scanning electron microscopy (SEM) imaging. The sensor exhibited very distinct oxidation potentials and excellent sensitivity with wide dynamic ranges of detection ranging from 10 nM to 5μ M and 1μ M to 5 mM with a very low limit of detections of 2.6 nM and 550 nM towards DA and UA respectively. The sensing mechanism can be ascribed to the simultaneous electro-oxidation process of DA and UA at the 3d orbital SnO6 octahedra sites facilitated with the Sn2+/Sn4+ oxidation states of Sn in line with the stress induced electrical property transformation of ZnSnO3 due to its piezoelectric nature. The as fabricated ZnSnO3/GCE sensor was further successfully evaluated for simultaneous detection of UA and DA in the simulated blood serum samples. This simple strategy for developing ZnSnO3 perovskite modified electrode paves way to develop electrochemical sensing platforms for bioanalytical applications. © 2001-2012 IEEE.