Here we report a platinum (Pt) nanoflowers decorated multiwalled carbon nanotubes (MWNTs)-graphene hybrid electrode based nonenzymatic sensor for the detection of glucose. MWNTs/graphene hybrid is synthesized by a one step chemical vapor deposition process via an in situ vapor-liquid-solid and surface-catalyzed mechanisms. Electrodeposition of Pt with optimized parameters at room temperature resulted in high density flower like nanostructures of Pt uniformly distributed over the hybrid electrode. Direct oxidation of glucose takes place due to the electrocatalytic property of the Pt nanoflowers resulting in the amperometric detection of glucose in the physiological range at neutral pH. The developed sensor responded linearly to glucose over the range of 1-7mM (R2=0.978) with a high sensitivity of 11.06μAmM-1cm-2. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.