A one-sided, nondestructive, ultrasonic technique for monitoring the setting and hardening process of concrete has recently been developed. The technique is based on monitoring the reflection coefficient of ultrasonic transverse waves at the surface of a laboratory scale hardening concrete in steel molds. The technique has been shown to reliably estimate the rate of strength gain of concrete under isothermal and outdoor conditions. Results of an experimental study to investigate the influence of curing temperature and mix design on the rate of strength gain and the ultrasonic transverse wave reflection loss are presented in this paper. Simultaneous measurements of wave reflection loss and compressive strength have been performed on various concrete compositions under different curing conditions. The ultrasonic technique is shown to produce reliable estimates of the rate of strength gain at early ages.