We present a no-reference (NR) image quality assessment (IQA) algorithm that is inspired by the representation of visual scenes in the primary visual cortex of the human visual system. Specifically, we use the sparse coding model of the area V1 to construct an overcomplete dictionary for sparsely representing pristine (undistorted) natural images. First, we empirically demonstrate that the distribution of the sparse representation coefficients of natural images have sharp peaks and heavy tails, and can therefore be modeled using a Univariate Generalized Gaussian Distribution (UGGD). We then show that the UGGD model parameters form good features for distortion estimation and formulate our no-reference IQA algorithm based on this observation. Subsequently, we find UGGD model parameters that are representative of the class of pristine natural images. This is achieved using a training set of undistorted natural images. The perceptual quality of a test image is then defined to be the likelihood of its sparse coefficients being generated from the pristine UGGD model. We show that the proposed algorithm correlates well with subjective evaluation over several standard image databases. Further, the proposed method allows us to construct a distortion map that has several useful applications like distortion localization, adaptive rate allocation etc. Finally and importantly, the proposed NR-IQA algorithm does not make use of any distortion information or subjective scores during the training process. © 2016 IEEE.