Nanodelivery is a well-known and efficient strategy andherein, we attempted to mimic this strategy using graphene-based nanoscrolls containing metal-organic frameworks (Zn3(BTC)2MOF) for efficient capture of heavy metal ions and inactivate bacterial cells in water. Zn3(BTC)2 and graphene scrolls have been used in different fields independently, yet the potential scope of these materials is unexplored. Mimicking metamorphosis of a caterpillar was adapted to design deliverable nanoscroll-encapsulated rod-like Zn3(BTC)2MOF. These constructs lead to targeted inactivation of bacterial cells by puncturing the cells showing a 3-log-fold reduction in E. coli and S. aureus. Additionally, after hydration, the activated porous MOFs result in scavenging heavy metals like lead and arsenic from water sources with a rejection > 99.5%. The uniqueness of these constructs was explored as an easy-to-deploy point of use device (hand-held and in-line kit) for water remediation applications. Copyright © 2019 American Chemical Society.