One of the challenges in rainfall-runoff modeling is the identification of an appropriate model spatial resolution that allows streamflow estimation at customized locations of the river basin. In lumped modeling, spatial resolution is not an issue as spatial variability is not accounted for, whereas in distributed modeling grid or cell resolution can be related to spatial resolution but its application is limited because of its large data requirements. Streamflow estimation at the data-poor customized locations is not possible in lumped modeling, whereas it is challenging in distributed modeling. In this context, semi-distributed modeling offers a solution including model resolution and estimation of streamflow at customized locations of a river basins with less data requirements. In this study, the Hydrologic Engineering Center-Hydrologic Modeling System (HEC-HMS) model is employed in semi-distribution mode on river basins of six different spatial resolutions. The model was calibrated and validated for fifteen and three selected flood events, respectively, of three types, i.e., single peak (SP), double peak (DP)-and multiple peaks (MP) at six different spatial resolution of the Sabari River Basin (SRB), a sub-basin of the Godavari basin, India. Calibrated parameters were analyzed to understand hydrologic parameter variability in the context of spatial resolution and flood event aspects. Streamflow hydrographs were developed, and various verification metrics and model scores were calculated for reference-and calibration-scenarios. During the calibration phase, the median of correlation coefficient and NSE for all 15 events of all six configurations was 0.90 and 0.69, respectively. The estimated streamflow hydrographs from six configurations suggest the model’s ability to simulate the processes efficiently. Parameters obtained from the calibration phase were used to generate an ensemble of streamflow at multiple locations including basin outlet as part of the validation. The estimated ensemble of streamflows appeared to be realistic, and both single-valued and ensemble verification metrics indicated the model’s good performance. The results suggested better performance of lumped modeling followed by the semi-distributed modeling with a finer spatial resolution. Thus, the study demonstrates a method that can be applied for real-time streamflow forecast at interior locations of a basin, which are not necessarily data rich. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.