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Microwave-Assisted Domino Povarov-Type [4+2] Cycloaddition: A Rapid Access to 7-Phenyl-6 H -chromeno[4,3- b ]quinolines
D.R. Kishore, K. Mounika, K. Goel, J. Naveen,
Published in Georg Thieme Verlag
2022
Abstract
A convenient, facile, and eco-friendly approach to synthesizing 7-phenyl-6H-chromeno[4,3-b]quinolines under microwave irradiation is presented. The current strategy enabled the synthesis of chromenoquinoline frameworks at 80 °C under shorter reaction times via intermolecular Schiff base formation followed by an intramolecular inverse demand hetero-Diels-Alder [4+2]-cycloaddition reaction by using a catalytic amount of copper triflate as the sole catalyst. Consequently, one C-N and two C-C bonds are constructed in a single pot, and a wide spread of 7-phenyl-6H-chromeno[4,3-b]quinolines have been synthesized with good functional group tolerance. © 2022 Georg Thieme Verlag. All rights reserved.
About the journal
JournalSynthesis (Germany)
PublisherGeorg Thieme Verlag
ISSN00397881