Tissue engineering is the promising therapeutic approach that combines cells, biomaterials, and microenvironmental factors to induce differentiation signals into surgically transplantable formats and promote tissue repair and/or functional restoration. Although several advances have been made in the field of tissue engineering, there are still significant challenges to be addressed in repairing or replacing tissues that serve predominantly biomechanical functions such as articular cartilage. One important obstacle that could be identified is with the scaffolds that play an important role in the extracellular matrix (ECM) but often fail to create the exact/conducive microenvironment during the engineered tissue development to promote the accurate in vitro tissue development. Therefore, the emerging challenge of engineered tissues is to rely on producing scaffolds with an informational function. In other words, informational polymers—the ones containing growth factors facilitating cell attachment, proliferation, and differentiation—are better than noninformational polymers. Growth factors help to manipulate the host healing response at the site of injury facilitating tissue repair and also improve the in vitro tissue growth in order to produce more biofunctional engineered tissues. The strategy is to mimic matrix and provide the necessary information or signaling for cell attachment, proliferation, and differentiation to meet the requirements of dynamic reciprocity for tissue engineering. Thus, proper drug delivery is a prerequisite in tissue-engineering applications. Biopolymers perform a diverse set of functions in their natural environment. To cite an example, proteins function as structural materials and catalysts; carbohydrates function in storage, maintain the functional integrity of membranes, and aid in intracellular communication (Yu et al. 2006). The properties displayed by biological materials and systems are exclusively determined by the physicochemical properties of the monomers and their sequence. In general, a well-defined macromolecular structure can lead to a rich complexity of function, and by virtue of their length and flexibility, they enable a unique control of hierarchical organization and long-range interactions. In many cases, the matrices and scaffolds would ideally be made of biodegradable polymers whose properties closely resemble those of the ECM which is a soft, tough, and elastomeric proteinaceous network that provides mechanical stability and structural integrity to tissues and organs (Guo et al. 2002). Biomaterials should possess mechanical properties capable of withstanding the forces and motions experienced by the normal tissues and have sufficient fatigue strength to ensure a long life of the implant in vivo. © 2013 by Taylor & Francis Group, LLC.