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Lipase mediated enzymatic degradation of polydioxanone in solution
A. Banerjee, K. Chatterjee,
Published in Elsevier Ltd
2014
Volume: 110
   
Pages: 284 - 289
Abstract
The enzymatic biodegradation of polydioxanone (PDO) in trifluoroethanol (TFE) at various temperatures (25-55°C) was studied with two different types of lipases, namely immobilized enzyme Novozym 435 and free enzyme porcine pancreas lipase. The biodegradation process was monitored by gel permeation chromatography (GPC). Both enzymes showed the optimum activity at 37°C and Novozym 435 exhibited better thermal stability over the experimental temperature range. A continuous distribution kinetic model was employed to describe the biodegradation process and the model was used to fit the experimental data satisfactorily and obtain kinetic parameters. © 2014 Elsevier Ltd. All rights reserved.
About the journal
JournalData powered by TypesetPolymer Degradation and Stability
PublisherData powered by TypesetElsevier Ltd
ISSN01413910