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Lewis Acid Mediated Domino Intramolecular Cyclization: Synthesis of Dihydrobenzo[ a]fluorenes
D.R. Kishore, C. Shekhar,
Published in American Chemical Society
2021
Volume: 86
   
Issue: 13
Pages: 8706 - 8725
Abstract
An efficient and facile method for the regioselective synthesis of novel dihydrobenzo[a]fluorenes from readily accessible alkynols is presented. The current strategy triggers the formation of a dual C-C bond intramolecularly via Lewis acid catalysis under mild reaction conditions. Notably, secondary as well as tertiary alcohols bearing an alkyne moiety have been smoothly transformed into the corresponding products. As a result, novel tetracyclic dihydrobenzo[a]fluorenes have been accomplished using this approach. ©
About the journal
JournalData powered by TypesetJournal of Organic Chemistry
PublisherData powered by TypesetAmerican Chemical Society
ISSN00223263