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Label-free chemiresistive biosensor for mercury (II) based on single-walled carbon nanotubes and structure-switching DNAPublished in AMER INST PHYSICS
2013
DOI: 10.1063/1.4773569
Volume: 102
Issue: 1
Herein, we present a sensitive, selective, and facile label-free DNA functionalized single-walled carbon nanotube (SWNT)-based chemiresistive biosensor for the detection of Hg2+. SWNTs were functionalized with Hg2+ binding 15-bases long polyT oligonucleotide through covalent attachment using a bilinker molecule. The polyT was further hybridized with polyA to form a polyT-polyA duplex. When exposed to Hg2+ the polyT-polyA duplex was dehybridized combined with switching of polyT structure, leading to change in resistance/conductance of the SWNT chemiresistor device. The device provided a significant response within 100 to 1000 nM of Hg 2+ concentration with a 6.72 × 10-3 nM-1 sensitivity. © 2013 American Institute of Physics.
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Content may be subject to copyright.This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publ... ...This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in [Label-free chemiresistive biosensor for mercury (II) based on single-walled carbon nanotubes and structure-switching DNA. Applied Physics Letters 102, 1 p013701 (2013)] and may be found at https://doi.org/10.1063/1.4773569.
About the journal
| Journal | Applied Physics Letters |
|---|---|
| Publisher | AMER INST PHYSICS |
| ISSN | 00036951 |
| Open Access | No |
Authors (1)
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