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Iron promoted C3-H nitration of 2H-indazole: direct access to 3-nitro-2H-indazoles
A. Murugan, K.R. Gorantla, , D.S. Sharada
Published in Royal Society of Chemistry
2018
PMID: 29978885
Volume: 16
   
Issue: 28
Pages: 5113 - 5118
Abstract
An efficient C3-H functionalization of indazole has been demonstrated. Notably, this method involves chelation-free radical C-H nitration on 2H-indazole. The radical mechanism was confirmed by control experiments and quantum chemical calculations. The synthetic utility has been proven by the synthesis of bio-relevant benzimidazoindazoles via reductive cyclization. © The Royal Society of Chemistry.
About the journal
JournalData powered by TypesetOrganic and Biomolecular Chemistry
PublisherData powered by TypesetRoyal Society of Chemistry
ISSN14770520