The single crystals of BaIn2Te4 have been synthesized at 1173 K using the sealed tube solid-state method. The polycrystalline sample of the compound was also synthesized by stoichiometric reaction of elements with intermittent grinding and annealing at 1123 K. The crystal structure of BaIn2Te4 has been established by single crystal X-ray diffraction study at 298(2) K. It crystallizes in space group D2h20−Cccm of the orthorhombic crystal system with unit cell dimensions of a = 7.1417(14) Å, b = 12.034(2) Å, and c = 12.107(2) Å with four formula units. The structure of BaIn2Te4 is related to the tetragonal binary TlSe structure (space group: I4/mcm). The crystal structure of BaIn2Te4 features one-dimensional chains of1∞[In2Te42−] that are separated by filling of Ba atoms. Indium atoms in these chains are surrounded by four Te atoms that form distorted tetrahedron geometry around In atoms. This compound does not show any homoatomic bonding and is having a closed shell electronic configuration. Thus, it can be easily charge balanced as Ba2+(In3+)2(Te2−)4. The phase purity of the polycrystalline BaIn2Te4 sample was established by the powder X-ray diffraction study. The direct band gap of 1.36(2) eV was estimated from the optical absorption study at room temperature. This ternary compound is an n-type semiconductor as suggested by the negative sign of the Seebeck coefficients (S). The absolute value of S was found to be decreasing on heating the polycrystalline BaIn2Te4 sample. The temperature-dependent resistivity study confirmed the semiconducting nature of the BaIn2Te4 sample. The thermal conductivity (κtot) values of polycrystalline BaIn2Te4 were found to be extremely low and were decreasing with raising the temperature with the lowest value of 0.30 Wm−1K−1 at 965 K. Hence, BaIn2Te4 and its analogs with related structures could be promising materials for thermoelectric applications by further optimization of carrier concentrations to improve electrical transport properties. © 2019 Elsevier B.V.