The fracture failure behavior of Hydroxyl-Terminated Polybutadiene (HTPB)- Ammonium Perchlorate (AP) interfaces is investigated as a function of strain rate. A rate dependent power law viscoplastic constitutive model of HTPB, AP and the HTPB/AP interface is characterized using nano-scale impact experiments at strain rates up to 100 s-1. A cohesive finite element method (CFEM) is used to predict the effect of strain rates and the interface chemistry on the interface fracture failure for a HTPB/AP sample with one AP particle. The cohesive parameters were obtained based on an in-situ mechanical Raman spectroscopy framework that measures cohesive strength and fracture energy correlation as a function interface chemistry. © 2017 ICF 2017 - 14th International Conference on Fracture. All rights reserved.