The diastereoselectivities in nucleophilic additions to bicyclo[2.2.2]octan-2-ones can be modulated by distal endo-substituents; both orbital and electrostatic interactions contribute to the observed stereoselectivity.

Faiz Ahmed Khan

Department of Chemistry

G. Mehta

B. Ganguly

J. Chandrasekhar

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IIT Hyderabad

Journal of the Chemical Society, Chemical Communications

Importance of orbital and electrostatic interactions in determining π-facial selectivities in nucleophilic additions to endo-substituted bicyclo[2.2.2]octan-2-ones

Journal	Journal of the Chemical Society, Chemical Communications
ISSN	00224936