We report for the first-time copper bismuth oxide (CuBi2O4) as an electrochemical sensor for the oxidation of uric acid and reduction of hydrogen peroxide. CuBi2O4 films are prepared on FTO via electrodeposition and used as a working electrode. Structural and morphological studies of CuBi2O4 were done by field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), X-ray photoelectron microscopy, tunneling electron microscopy (TEM). Electrochemical studies were performed using cyclic voltammetry (CV), chronoamperometry with CuBi2O4 electrode for the detection of uric acid (UA) and hydrogen peroxide (HP). High sensitivities of 206.7 and 280.6 μA mΜ-1 cm−2 were achieved for the detection of UA and HP. Therefore, CuBi2O4 can be a potential candidate to explore for sensing applications. © 2021 Elsevier B.V.