We describe here a convenient and mild procedure for double carbonylation of o-dibromobenzenes with various 2-amino pyridines and naturally occurring amines, thus providing in good to excellent yields N-substituted phthalimides by using this palladium-catalyzed carbonylation procedure. Furthermore, for the first time we have applied the developed synthetic protocol for the synthesis of biologically active molecule thalidomide via a single step carbonylative cyclization reaction in excellent yield. © the Partner Organisations 2014.

Natte Kishore

Department of Chemistry

J. Chen

A. Spannenberg

H. Neumann

M. Beller

X.-F. Wu

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IIT Hyderabad

Organic and Biomolecular Chemistry

Efficient palladium-catalyzed double carbonylation of o-dibromobenzenes: Synthesis of thalidomide

Journal	Data powered by TypesetOrganic and Biomolecular Chemistry
Publisher	Data powered by TypesetRoyal Society of Chemistry
ISSN	14770520