We study the failure at interfaces between Hydroxyl-terminated polybutadiene (HTPB)-Ammonium Perchlorate (AP) based energetic material. In this work, interface mechanical strength of a set of HTPB-AP interfaces is characterized using nano-scale impact experiments at strain rates up to 100 s−1. A power law viscoplastic constitutive model was fitted to experimental stress-strain-strain rate data in order to obtain constitutive behavior of interfaces, particle, and matrix. A mechanical Raman spectroscopy is used to analyze the effect of binding agent at different temperature. A tensile fracture experiment combined with In-situ Mechanical Raman Spectroscopy was used to obtain fracture properties. Stress maps are obtained near the interface using In-situ Mechanical Raman Spectroscopy to analyze the changes in the stress distribution around interfaces for different loads till failure. Cohesive zone model parameters were obtained from the consideration of local stress during failure and the cohesive energy required for delamination of AP from HTPB matrix. Effect of binding agent on the interface strength is found to be quite significant. The cohesive zone parameters and the viscoplastic model obtained from the experiment were then used in the cohesive finite element method to simulate the dynamic crack propagation as well as the delamination. Results show that interfacial properties are affected by the rate of loading and are also dependent upon the binding agent. © 2018, The Society for Experimental Mechanics, Inc.