Cardiovascular diseases (CVD) are the prime cause of the high mortality rate across the world. Clinical CVD identification is, generally, done by exploitation of either Standard 12-Lead (S12) or Mason–Liker 12-Lead (ML12) Electrocardiogram (ECG) system. However, acquisition of these 12-lead ECG is cumbersome and time consuming process. In remote health monitoring cases, 12-lead ECG requires high bandwidth, storage and data transmission time. Thus to mitigate these, synthesis of 12-lead ECG from reduced lead set has been investigated over the past decade. This chapter identifies and review on the state of the art methodologies that exists in the literature. © Springer Nature Singapore Pte Ltd. 2022. All rights are reserved.