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Dual C-C Bond Forming Heck and Sonogashira Couplings Followed by Hydroarylation: Synthesis of Tricyclic Frameworks
K. Ramesh, D. Ravikishore,
Published in Wiley-Blackwell
2020
Volume: 5
   
Issue: 8
Pages: 2430 - 2434
Abstract
Herein, a concise approach to construct the novel tricyclic ether frameworks, is presented. Microwave-assisted dual C-C bond-forming palladium-catalyzed intramolecular Heck/intermolecular Sonogashira couplings were implemented, for the synthesis of dihydrobenfurans bearing acetylene moiety, followed by acid-induced intramolecular hydroarylation reaction of the crude reaction mixture furnished the tricyclic ether systems. Notably, these tricyclic ether frameworks have been achieved, in excellent yields, through a single column chromatography process. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
About the journal
JournalData powered by TypesetChemistrySelect
PublisherData powered by TypesetWiley-Blackwell
ISSN23656549