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Domino [Pd]-Catalysis: Heck followed by decarboxylative Sonogashira couplings under microwave irradiation in aqueous medium
Published in Elsevier B.V.
2019
Volume: 890
   
Pages: 58 - 71
Abstract
A copper free [Pd]-catalyzed domino intramolecular Heck and intermolecular decarboxylative Sonogashira couplings, for the synthesis of alkyne bearing heterocyclic compounds with a quaternary carbon atom, is described. Notably, this dual bond forming strategy is successful in water solvent, under microwave irradiation. This one-pot operation enabled the formation of a variety of dihydrobenzofurans, indolines and oxindoles, in very good to near quantitative yields. Notably, unlike earlier reports, the present strategy is successful in delivering the products with short alkyl substituents on acetylene carbon, which is first of its kind. © 2019 Elsevier B.V.
About the journal
JournalData powered by TypesetJournal of Organometallic Chemistry
PublisherData powered by TypesetElsevier B.V.
ISSN0022328X