We report chemical sensors based on solution processed organic field-effect transistors (OFETs) for detecting volatile organic compounds (VOCs). The OFETs were prepared on flexible plastic substrates and operated at low voltages (≤3 V) with high performance. These OFETs can be used to detect a range of VOCs, including alcohols and ketones. The sensitivity of these devices depends on the polarity of the analytes, and more hydrophobic analytes with longer alkyl chains show higher sensitivities than those with shorter alkyl chains. Arrays of these devices are suitable for portable sensor applications, such as environmental monitoring, food quality monitoring, and medical diagnostics. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.