We report the synthesis and site-specific incorporation in oligodeoxynucleotides (ODNs) of an emissive deoxyuridine analog electronically conjugated on its C5-position with a 3-methoxychromone moiety acting as a fluorophore. When incorporated in ODNs, this fluorescent deoxyuridine analog exhibits remarkable photostability and good quantum yields. This deoxyuridine analog also displays a mega-Stokes shift, which allows for its use as an efficient donor for FRET-based studies when paired with the yellow emissive indocarbocyanine Cy3 acceptor. © 2016 American Chemical Society.

Krishna Gavvala

Department of Chemistry

N.P.F. Barthes

D. Bonhomme

A.S. Dabert-Gay

D. Debayle

Y. Mély

B.Y. Michel

A. Burger

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Journal of Organic Chemistry

Design and Development of a Two-Color Emissive FRET Pair Based on a Photostable Fluorescent Deoxyuridine Donor Presenting a Mega-Stokes Shift

Journal	Data powered by TypesetJournal of Organic Chemistry
Publisher	Data powered by TypesetAmerican Chemical Society
ISSN	00223263