Header menu link for other important links
X
Covariate-adjusted response-adaptive designs for censored survival responses
A. Mukherjee, D.S. Coad,
Published in Elsevier B.V.
2023
Volume: 225
   
Pages: 219 - 242
Abstract
Covariate-adjusted response-adaptive designs use the available responses to skew treatment allocation in a clinical trial, in favour of the treatment, found at an interim stage of the trial, to be best for a patient's covariate profile. In this study, such designs are developed for censored Weibull responses. The designs are based on the covariate-adjusted doubly-adaptive biased coin design and the covariate-adjusted efficient randomized-adaptive design. The treatment allocation proportion for these designs, converges empirically to the expected target value. An extensive simulation study of the operating characteristics of these designs demonstrates that they can be considered as suitable alternatives to traditional balanced randomization designs, provided responses related to the primary endpoint are available during the recruitment phase to enable adaptations in the design. An existing clinical trial is redesigned using the proposed methodology to illustrate its implementability in real-life scenario. © 2023 Elsevier B.V.
About the journal
JournalJournal of Statistical Planning and Inference
PublisherElsevier B.V.
ISSN03783758