Evaporation of a single droplet of a binary mixture of ethanol/iso-octane was numerically studied. Liquid/gas interface was tracked using VOF multiphase model. As ethanol and iso-octane form a highly non-ideal mixture, vapour-liquid-equilibrium (VLE) calculations were made using UNIFAC group contribution method. Source terms arising due to interfacial mass transfer are implemented in the continuity, momentum, energy and species equations. In this study, commercial CFD solver, Ansys Fluent 12.1 was used. VLE calculations and the source terms were implemented using user defined functions. A non-isothermal flow condition with droplet and surrounding medium at different temperatures was studied. Time history of temperature, evaporation rate, droplet size and shape were studied and reported. A parametric study of droplet composition and Reynolds number has been performed and reported in this study. Copyright © 2011 by ASME.