The performance of a fuel cell critically depends on the removal of CO from the feed hydrogen because the preferential adsorption of CO over the catalyst takes place resulting in a reduction of the power output of the cell. Therefore, it is important to treat the fuel cell feed hydrogen to reduce its CO content below the tolerable limit. The development of efficient catalysts for the treatment of synthesis gas for the removal of CO and hydrogen is important. In this chapter, we discuss various strategies for producing hydrogen from different sources. The advantages and disadvantages of these methods are discussed. One of the various possible strategies for the removal of CO from the synthesis gas can be the judicious use of the water-gas shift reaction. We discuss possible catalysts for this reaction and discuss the kinetics of these reactions by proposing relevant reaction mechanisms. © 2013 Elsevier B.V. All rights reserved.